Joyce Brewster   Barbra Streisand
Andrew Brewster   Seth Rogen
kmart Receptionist   Julene Renee-Preciado
kmart Executive   Zabryna Guevara
kmart Executive   John Funk
kmart Executive   Robert Curtis Brown
Gayle   Kathy Najimy
Anita   Miriam Margolyes
Diana   Rose Abdoo
Mature Singles Man   Tom Virtue
Mature Singles Woman   Vivian Vanderwerd
Bob   Worth Howe
Young Joyce   Vicki Goldsmith
Toddler Andy   Matthew Levinson
Toddler Andy   Joseph Levinson
Budget Car Renter   Kevin O'Keefe
Mark   Rick Gonzalez
Middlesex Voice Over (Stimme)   Jeff Witzke
Amanda   Casey Wilson
OSH Executive   Steve Tom
Viriginia Hotel Clerk   David Boller
Stripper   Gabrielle Gumbs
Tammy   Dale Dickey
Moonlight   Analeis Lorig
Jessica   Yvonne Strahovski
Rob   Colin Hanks
Ryan Mcfee   Brandon Keener
Jimmy   Jeff Kober
Hitchhiker   Pedro Lopez
Amy   Nora Dunn
Andrew Margolis, Jr.   Adam Scott
Joyce Margolis   Ari Graynor

Regie    Anne Fletcher
Buch    Dan Fogelman
Kamera    Oliver Stapleton
Schnitt    Dana E. Glauberman
Priscilla Nedd-Friendly
Musik    Christophe Beck