Cast & Crew zu Spider-Man
| Spider-Man/Peter Parker | Tobey Maguire | |
| Green Goblin/Norman Osborn | Willem Dafoe | |
| Mary Jane Watson | Kirsten Dunst | |
| Harry Osborn | James Franco | |
| Uncle Ben | Cliff Robertson | |
| Aunt May | Rosemary Harris | |
| J. Jonah Jameson | J.K. Simmons | |
| Flash Thompson | Joe Manganiello | |
| Maximilian Fargas | Gerry Becker | |
| Joseph 'Robbie' Robertson | Bill Nunn | |
| Henry Balkan | Jack Betts | |
| Gen. Slocum | Stanley Anderson | |
| Dr. Mendell Stromm | Ron Perkins | |
| Carjacker | Michael Papajohn | |
| Ellie Simkins | K.K. Dodds | |
| Hoffman | Ted Raimi | |
| Wrestling ring announcer | Bruce Campbell | |
| Betty Brant | Elizabeth Banks | |
| Osborn's houseman | John Paxton | |
| Philip Watson | Tim De Zarn | |
| Madeline Watson | Taylor Gilbert | |
| Bone Saw McGraw | Randy Poffo | |
| Wrestling promoter | Larry Joshua | |
| Herself | Macy Gray | |
| Punk rock girl | Lucy Lawless | |
| Subway guitarist | Jayce Bartok | |
| Sunglasses vendor | Stan Lee | |
| Grau dargestellte
Schauspieler spielen im Film mit, werden aber nicht im Abspann erwähnt. |
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| Regie |
Sam Raimi |
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| Buch |
Stan Lee Steve Ditko |
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| Drehbuch |
David Koepp |
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| Kamera |
Don Burgess |
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| Schnitt |
Arthur Coburn Bob Murawski |
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| Musik |
Danny Elfman |
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| Greensperson | Amy Safhay | |
| Wire Removal | James David Hattin | |
| Fight Choreographer | Chuck Jeffreys | |
| Main Title Design | Imaginary Forces/Kyle Cooper | |